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Congratulations to Marie Haufroid and Elise Pierson who presented the “Best Communication” entitled "Study of the inhibition of Mycobacterium tuberculosis SerB2 (phosphoserine phosphatase): identification of new potential inhibitors" at the Journées Franco-Belges de Pharmacochimie 2017.

Last publications

1. Rogez-Florent, T., et al., New selective carbonic anhydrase IX inhibitors: Synthesis and pharmacological evaluation of diarylpyrazole-benzenesulfonamides. Bioorganic and Medicinal Chemistry, 2013. 21(6): p. 1451-1464.
2. Pochet, L., et al., Determination of inhibitory potency of argatroban toward thrombin by electrophoretically mediated microanalysis. Talanta, 2013. 116: p. 719-725.
3. Mejia, J., et al., Dose assessment of SiC nanoparticle dispersions during in vitro assays. Journal of Nanoparticle Research, 2013. 15(8).

  • Rondelet, G. & Wouters, J 2017  'Human DNA (cytosine-5)-methyltransferases: a functional and structural perspective for epigenetic cancer therapy' Biochimie. p. 137-147
  • Harmsen, B., Robeyns, K., Wouters, J. & Leyssens 2017 ' A Study of Fasoracetam's Solid State Forms: A Potential Anti-Alzheimer Pharmaceutical' Journal of Pharmaceutical Sciences. 106, 5, p. 1317-1321
  • Carvalho, A., Chu, J., Meinguet, C., Kiss, R., Vandenbussche, G., Masereel, B., Wouters, J., Kornienko, A., Pelletier, J. & Mathieu, V 2017 ' A harmine-derived beta-carboline displays anti-cancer effects in vitro by targeting protein synthesis' European Journal of Pharmacology. 805, p. 25-35 11
  • Rondelet, G., Fleury, L., Faux, C., Masson, V., Dubois, J., Arimondo, P. B., Willems, L. & Wouters, J. 2017, 'Inhibition studies of DNA methyltransferases by maleimide derivatives of RG108 as non-nucleoside inhibitors' Future Medicinal Chemistry. 9, 13, p. 1465-1481
  • Bouckaert, C, Serra, S, Rondelet, G, Dolusic, E, Wouters, J, Dogne, J-M, Frédérick, R & Pochet, L 2016, 'Synthesis, evaluation and structure-activity relationship of new 3-carboxamide coumarins as FXIIa inhibitors' European Journal of Medicinal Chemistry. DOI: 10.1016/j.ejmech.2016.01.023
  • Rondelet, G, Dal Maso, T, Willems, L & Wouters, J 2016, 'Structural basis for recognition of histone H3K36me3 nucleosome by human de novo DNA methyltransferases 3A and 3B' Journal of Structural Biology. 194(3), 357-67 DOI: 10.1016/j.jsb.2016.03.013
  • Sooriyaarachchi, S., Chofor, R., Risseeuw, M. D. P., Bergfors, T., Pouyez, J., Dowd, C. S., Maes, L., Wouters, J., Jones, T. A., Van Calenbergh, S. & Mowbray, S. L. 2016 'Targeting an Aromatic Hotspot in Plasmodium falciparum 1-Deoxy-d-xylulose-5-phosphate Reductoisomerase with β-Arylpropyl Analogues of Fosmidomycin' ChemMedChem. p. 2024-2036 13 p.

Last theses

  • Etude structurale de la synthèse d'imines et phtalimides par mécanochimie. Jean DUBOIS (présentée en 2017)
  • Etude structurale d'inhibiteurs non-nucléosidiques des ADN (cytosine-5) méthyltransférases, Grégoire RONDELET (présentée en 2016)
  • Conception, synthèse, caractérisation, évaluation pharmacologique et étude in vivo de dérivés de l’harmine en tant que nouvelles molécules aux propriétés anticancéreuses, Céline MEINGUET (présentée en 2015)
  • Caractérisation structurale et étude de l’inhibition de la 1-déoxy-D-xylulose-5-phosphate reductoisomérase (DXR) de E.coli et de la DXR-like de B.abortus, par des analogues de la fosmidomycine, Jenny POUYEZ (présentée en 2014)
  • Structural characterization of cyclodextrins : from inclusions complexes to Metal-Organic Frameworks (MOFs), Kossay ELASAAD (présentée en 2013)
  • Étude physico-chimique et structurale de la cocristallisation de molécules-modèles de principes actifs potentiels, Anaelle TILBORG (présentée en 2013)
  • Conception, synthèse et étude d’inhibiteurs de la tryptophane 2,3-dioxygénase (TDO), une cible prometteuse pour le traitement du cancer, Moineaux Laurence, 30 janvier 2013

 

 

 

Towards innovative new drugs ...

The research of effective and innovative drugs remains a major challenge in health. With this ambitious objective in mind, was established the Namur Medicine & Drug Innovation Center (NAMEDIC), a new research center of the University of Namur.

Multidisciplinary center

The activities are highly multidisciplinary, involving in particular the research of new hits, the design of computer-aided drug, organic synthesis of new molecules, the pharmaceutical analysis and the pharmacology.